Researchers quantitatively assessed for the first time that somatic mutations alone cap human lifespan at 146–194 years. Brain and heart cells are the main bottleneck, while the liver could last millennia.

Explain Like I'm Normal

Researchers used quantitative modeling to determine that DNA damage in non-dividing cells creates a hard ceiling for human life around 150-200 years. While our livers are theoretically built for centuries, our brains and hearts act as the primary bottlenecks for biological immortality. This data provides a concrete target for future AGI-driven longevity research aiming to surpass natural human limits.